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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RFC1 All Species: 28.48
Human Site: S428 Identified Species: 56.97
UniProt: P35251 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35251 NP_002904.3 1148 128255 S428 I E R D E A K S L I E R Y G G
Chimpanzee Pan troglodytes XP_001140765 1148 128250 S428 I E R D E A K S L I E R Y G G
Rhesus Macaque Macaca mulatta XP_001091287 1148 128475 S428 I E R D E A K S L I E R Y G G
Dog Lupus familis XP_536259 1145 128125 S425 I E R D E A K S L I E R Y G G
Cat Felis silvestris
Mouse Mus musculus P35601 1131 125967 S425 I E R D E A K S L I E R Y G G
Rat Rattus norvegicus NP_445999 1131 125770 S423 I E R E E A K S L I E R Y G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512744 1233 136122 C511 I E R D E A K C L I E R H G G
Chicken Gallus gallus NP_001006456 1147 128454 S425 I E R D E A K S L I E R Y G G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35600 986 108596 K324 K Q V K E E K K S P K K E H S
Honey Bee Apis mellifera XP_397246 911 103001 E249 L D S L E R E E A E E L V K Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797949 906 99249 T244 T K R V T R S T P T K P P P A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38630 861 94885 V199 I S S K T S V V V L G D E A G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.3 89.3 N.A. 82.4 81.3 N.A. 67.4 68.9 N.A. N.A. N.A. 39.9 36.2 N.A. 38
Protein Similarity: 100 99.6 98.5 93.7 N.A. 89.5 88.5 N.A. 77.2 79.6 N.A. N.A. N.A. 55.9 53.6 N.A. 52.2
P-Site Identity: 100 100 100 100 N.A. 100 93.3 N.A. 86.6 100 N.A. N.A. N.A. 13.3 13.3 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 100 N.A. N.A. N.A. 33.3 33.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 67 0 0 9 0 0 0 0 9 9 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 59 0 0 0 0 0 0 0 9 0 0 0 % D
% Glu: 0 67 0 9 84 9 9 9 0 9 75 0 17 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 9 0 0 67 75 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 9 9 0 % H
% Ile: 75 0 0 0 0 0 0 0 0 67 0 0 0 0 0 % I
% Lys: 9 9 0 17 0 0 75 9 0 0 17 9 0 9 0 % K
% Leu: 9 0 0 9 0 0 0 0 67 9 0 9 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 9 9 0 9 9 9 0 % P
% Gln: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 9 % Q
% Arg: 0 0 75 0 0 17 0 0 0 0 0 67 0 0 0 % R
% Ser: 0 9 17 0 0 9 9 59 9 0 0 0 0 0 9 % S
% Thr: 9 0 0 0 17 0 0 9 0 9 0 0 0 0 0 % T
% Val: 0 0 9 9 0 0 9 9 9 0 0 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 59 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _